SwissSidechain is a structural and molecular mechanics database of hundreds of non-natural amino-acid sidechains that can be used to study in silico their insertion into natural peptides or proteins.
Structural files (pdb, mol2, rotamers) for 230 sidechains (both D and L) can be found together with PyMOL and UCSF Chimera plugins to insert them into existing peptide or protein structures. In addition, predicted rotamers as well as all topologies/parameters required to run detailed molecular mechanics analysis with Gromacs and CHARMM are provided.